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By covalently modifying membrane-associated proteins, the membrane lipid peroxidation product 4-hydroxynonenal (HNE) may play particularly sinister roles in the metabolic syndrome and associated disease processes.

While SUMO is present throughout development, early Drosophila embryos contain particularly high concentrations of maternally contributed SUMO and the enzymes required for SUMO conjugation [16], [24], [25], suggesting that sumoylation may play particularly critical roles at this stage of fly development.

Together the data reported here indicate that cytokine expression potential of splenoctyes may play particularly important roles in the ability of SWR mice to handle an increased lipid load without increasing weight or lipid deposition or any apparent pro-inflammatory response.

131 Indeed, differential age, period, and cohort effects in educational and occupational attainment may play particularly important roles for late-life cognitive trajectories and risk of AD.

Those genes that show differential expression may play particularly important roles in the development of breast cancer and in determining breast cancer resistance or sensitivity to cytotoxic therapy.

Thus, conserved signatures in the sequences of groups of FeSODs and MnSODs suggest that a few residues may play particularly important roles in determining which metal ion is active, and observed correlations offer predictions that can be tested by mutagenesis.

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(Kozinn) ★ Murray Perahia (Sunday) The pianist Murray Perahia may not play particularly adventurous programs.

The Lib Dems do well with such voters on Iraq, on their hostility to tuition fees, and for defending civil liberties and immigration.In some Labour seats in the Midlands and the North-West with a concentration of Muslim voters, Iraq may still play particularly strongly.

Long-term acute care hospitals (LTACHs) may play a particularly important role in the spread of KPC-producing Enterobacteriaceae, particularly among neonates or patients with a serious illness who have a reduced immune system functional capacity and who are undergoing invasive examinations or treatments.

This, in addition to the demonstration that multiple enhancer SNPs can act in combination to impact gene expression, suggests that epistatic effects between noncoding variants may play a particularly important role for enhancer loci, especially when enhancer variants of the same gene are inherited independently.

But in some cases - such as that of the Malaysia Airlines flight MH370, which went missing in March - other countries may play a particularly important part, thanks to their resources, their technical knowledge or the political dimension of the incident.

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