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Previous studies have indicated that genes that are duplicated by tandem duplication events may play distinct roles in plant development and response to abiotic and biotic stresses37.
Furthermore, we provide evidence that individual HIF transcription factors may play distinct roles in the development of specific VHL disease manifestations.
Not only is the joint an organ system, sub-regions within each joint tissue, especially the joint lining, may play distinct roles in damage and repair.
Monoaminergic cells of brainstem and basal forebrain have widespread projections to thalamus and cortex (Saper 1987) and may play distinct modulatory roles in the regulation of sleep and arousal (McCormick and Bal 1997).
In fact, these two glia cells may play distinct roles in Aβ clearance depending on amyloid aggregation states and pathogenesis stages.
In summary, our results suggest that MmTKL1 and MmTKL2 may play distinct and complementary roles in M. megachiliensis defense against environmental stress, mediated by induction of erythritol production.
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At any rate, we speculate that the two groups of orexigenic neurons may possibly play distinct roles with regards to modulation of cannabinoid-induced effects.
These findings also raise the possibility that other IPs may also play distinct roles in modulating B cell physiology.
Two of these, CASP8 and ERBB3, have been reported to directly interact with H5N1 viral proteins but not H1N1 proteins even though the H1N1-human PPI have much greater coverage, suggesting that they may indeed play distinct roles.
It has been hypothesized that CR cells born at these sites populate different cortical regions and may thus play distinct, region-specific roles in neocortical development (Bielle et al. 2005).
The present finding that MGL, a regulator of at least two major brain signaling pathways (Mulvihill & Nomura, 2013), is located within at least four major synapse types supports the idea that this serine hydrolase may indeed play distinct physiological functions at different circuit locations.
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