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However, the typical migraine aura cannot be directly explained by brainstem events, but rather by cortical spreading depression (CSD) [9], for which not only potassium ions and/or glutamate may play central roles, but also other ions and transmitters, including NO [10].
Aβ-induced cellular redistribution and inactivation of m-HKI may play central roles in oxidative stress and neurodegeneration in AD.
This finding suggests that continuous, spontaneous stimulation of EGFR and Her2 signaling may play central roles in particularly dangerous and metastatic breast cancer tumor types.
For instance, several plant hormones may play central roles in the control of ripening in the grape berry [ 52].
Endothelial damage and activation may play central roles in the pathogenesis of systemic sclerosis (SSc) and are reflected by microparticles (MPs) and soluble selectins.
Epigenetic factors, including DNA methylation, histone modifications, and microRNA expression, may play central roles in controlling changes in gene expression and genomic instability during aging.
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In some cultures, religion may play a central role in the formation of a disability culture.
The sensory organ may play a central role in coordinating a whale's body parts into an efficient machine.
Imprinting, far from being a genetic curiosity, may play a central role in sexual differences and in psychiatric disease, if Dr. Haig's explanation is correct.
Suicide risk may play a central role in affecting the quality of life of patients with chronic headache.
Several molecules have been involved in liver regeneration, and among them bile acids may play a central role.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com