Moreover, FISH and immunocytochemical techniques can underestimate the number of genetic loci or replisomes, while the binding of fluorescent proteins to DNA, used to visualize genetic loci, may perturb replication or segregation of a locus (Possoz et al., 2006; Woldringh and Nanninga, 2006).
Thus, any residue mutation in the P2 region that will affect the stable binding of Tm-actin at the closed and open state or residues or that may perturb its interaction with the myosin head domain could lead to a disease phenotype.
This finding lends support to the associations observed in our study, but also suggest that the identified candidate network should be further investigated based on the hypothesis that multiple variants independently or combined may perturb the biological activity of the network.
As a result, many studies have demonstrated that solubilization of MPs with detergents may perturb their structure, influence their dynamics, or lead to aggregation.
The Fab1p-, and18p-, and Vac7p-binding sites may overlap, or the vac14 L149R mutation may perturb the surrounding structure, altering the Fab1p-binding site and a separate Atg18p/Vac7p-binding site.
Current evidence suggests that PsA occurs in a genetically primed individual in whom stress or entheseal-derived antigens may perturb the immune response, resulting in angiogenesis, T-cell infiltration and cytokine release.
A sub- or supra-optimal glucose signaling may perturb the normal gravitropic response exhibited by the wild-type seedlings.
These results are consistent with the model that EAT-6 functions in both the bodywall muscles and the ACh neurons, and that either increased or decreased EAT-6 function may perturb ACh neurotransmission.
If the cell size of the ancestral population was preliminarily evolved or optimized for growth, size selection may perturb it as the result of evolutionary trade-offs.
