Using this approach, we identified a panel of high-confidence candidate SNPs that may perturb the expression of autism-implicated genes.
While not amenable to high-throughput screening, global analysis methods such as ChIP-seq and Chem-seq are important approaches to define how target proteins and small-molecule inhibitors may perturb specific gene expression program [ 39, 40].
Noise in the biochemical processes underlying growth and division, such as that created by stochastic gene expression, may perturb the control of size and affect the distribution of cell size.
To examine the suggestion that dSpt1 C129W expression may perturb ER to Golgi trafficking affecting sensory function, we introduced a known effector of ER to Golgi membrane trafficking, Rab1.
The interaction between chemicals and cellular membranes may perturb receptor signalling inducing changes in the expression of genes encoding for signalling components and ultimately creating an unbalance in the expression of effectors pathways involved in tissue dynamics and homeostasis.
First, the non-physiological expression of reporter gene proteins may perturb the critical SC cellular and therapeutic functions.
However, in Ncadk.i. and Ncadk.i. p53, CFTR expression is greatly reduced, which may perturb lipid secretion as visualized by Oil Red staining.
Interestingly, it appeared that verapamil had some propensity to modulate P-gp expression (Fig. 5a), suggesting that it may perturb P-gp function through mechanisms other than direct inhibition of the efflux protein.
Damage to the vessel walls themselves may perturb skin circulation.
The diffuse multipath returns from rough walls may perturb the range-profile and hence the time-delay estimates, which in turn will perturb the target location estimates.
