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While the expression levels of this variant has not been characterised we speculate that it is possible that this substitution would open up the adenosine- binding pocket and may permit binding of the alternative cofactor NADP+.
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However, acid treatment may permit intracellular binding.
Two conserved domains (C1 and C2) permit binding of a host of proteins that may be common to all syndecans whilst a variable domain (V) allows interaction with proteins unique to each syndecan.
These proteins may function as chaperones, altering or maintaining specific RNA structures that permit binding of the translational machinery (for review see [10]).
The significance of the larger BtMinpp ligand-binding site is that it may permit alternate substrate binding modes.
This bond was essential for orientating the peptide into the positively-charged binding pocket on Cbl, to permit binding.
Golgi-Rab binding sites may permit GCC185 to contribute to stacking and lateral interactions of Golgi cisternae as well as help it function as a vesicle tether.
Interestingly, these residues are also involved in interactions with certain UBDs 20a– d and may permit the initial latching in respective binding processes.
G6 has a "misplaced" Cys2 (archetypal) and lack of this Cys2 is responsible for the functional flexibility of the Kunitz-domain binding loop, that may permit target-specific interactions other than the catalytic domain of serine proteases [ 53].
The mechanical coupling between FN fibril formation and disruption of cell-FN adhesions may permit cells to reiterate this process of binding, pulling, and detaching on additional neighboring FN molecules.
In this case, the "main door" may be nonfunctional and may permit SPGB3N to escape the hBChE substrate binding site before reaction occurs with the active site serine.
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CEO of Professional Science Editing for Scientists @ prosciediting.com