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Instead, we speculate that changes in mitochondrial Zn pools may perform regulatory functions to modulate the phenotype of the highly differentiated secretory epithelium during lactation.
Thus, similarly to secreted miRNAs, long noncoding RNAs may perform regulatory functions in the target cells.
Previous studies have showed that isomiRs may perform regulatory functions between different libraries [ 19, 20].
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Presence of transposable elements within introns in genes of cereals may perform similar regulatory functions.
The species specificity of these miRNAs suggests that they may perform a regulatory function that is unique to adipose tissue metabolism in Bos taurus or other ruminants.
It would be reasonable to conclude that the AHR possesses a set of endogenous functions that are independent of its activation as a transcription factor by xenobiotic ligands and that these functions may perform a regulatory role during development.
Indeed, secreted miRNAs may target neighboring cells and perform regulatory functions in them [ 3, 19, 20].
miRNAs that vary by single or multiple residues, especially in the seed region (position 2 8), can have a different target spectrum and may perform very different regulatory functions since minor changes in sequence could remarkably affect target specificity or regulatory efficiencies.
The large number of stem/progenitor cells with nucleostemin expression could be of general importance in proliferation maintenance in all tendon regions, while the few stem/progenitor cells with Oct 3/4 expression, mainly seen inside the I region, may perform a more specific regulatory role in the healing tendon.
A transcriptional regulation domain at the C-terminal region may perform diverse functions because of its interactions with different regulatory proteins and activation of gene expression [ 10, 14, 19, 20].
This finding illustrated that these genes may perform different functions in response to different stimuli, and implied that wheat triggered distinct genes and regulatory networks to antagonize Bgt and Pst infection.
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