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Forced overexpression of prostasin greatly reduces cancer cell survival, and may partially reverse chemoresistance.
Nevertheless, long-term treatment of hypertension may partially reverse this rightward shift.
Early phase clinical trials also suggest that addition of decitabine to a platinum agent may partially reverse platinum-resistance in advanced ovarian carcinomas [ 41- 43].
The data suggest that restoration of prostasin in chemoresistant cells inhibits growth of these tumors and may partially reverse chemoresistance, which is consistent with our in vitro findings.
In vivo studies indicate that forced overexpression of prostasin in drug-resistant cells greatly inhibits the growth of tumors and may partially reverse drug resistance.
The recovery of cellular immunity with HAART may partially reverse susceptibility to opportunistic infections when it achieves sustained undetectable levels of HIV-RNA and CD4+ levels above 500 cells/mm over a long period of time [ 9, 11].
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Exposures to higher levels (e.g., 40 ppm) can produce a burning sensation in the nose and throat, dyspnea, and severe airway obstruction that may only partially reverse over time [ 31].
The novel nonsense type of mutation that we found enabled us to test the proof of principle that interventions designed to read through premature stop mutations may at least partially reverse a clinical phenotype.
(Later, as the stock of capital grows in response, that effect may be partially reversed).The economic conditions now seem propitious for an enormous further expansion of migration.
Hierarchical linear modeling (HLM) analyses suggest that while screening rates decreased with age (OR, 0.957; 95% CI, 0.947-0.968) cohort effects may have partially reversed the age effect, with non-baby boomers having an increased likelihood of receiving a mammogram compared to baby boomers (OR, 1.697; 95% CI, 1.278-2.254).
Our study demonstrates that: i) pharmacological or genetic inhibition of HO-1 impairs healing of cutaneous wounds in mice; ii) induction of HO-1 in response to injury is impaired in diabetic mice, in which wound healing is delayed; iii) this delay may be partially reversed by HO-1 overexpression, the effect associated with increased vascularization of the wounded tissue.
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may partially offset
may partially decrease
may partially contribute
may partially relieve
may partially explain
may partially ameliorate
may partially solve
may partially compensate
may partially affect
may partially regulate
may partially replace
may partially be
may partially mute
may partially drive
may partially silence
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com