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Clinical data suggest that bortezomib and, to a lesser extent, lenalidomide may partially overcome the poor prognosis conferred by the t(4 14) translocation, although there are discrepancies among the various studies, and prospective analyses are clearly needed to determine the true impact of these agents on patients with this abnormality.
Additional strategies such as infection causing increases in feeding rate as documented for malaria [ 8] and West Nile virus (WNV;[ 9]) may partially overcome the costs of virulence on pathogen transmission, yet ultimately pathogen evolution should move towards the balance between virulence and pathogen load which maximizes transmission.
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Nevertheless, our findings raise the question of whether drug resistance selected by sdNVP may be partially overcome with complete adherence.
However, this limitation may be partially overcome by using mesocarp markers as a whole, therefore increasing their discriminating power.
Limitations in sensitivity and specificity of individual markers may be partially overcome by considering a panel of molecules that are individually predictive of breast cancer risk.
In some patients the negative impact of a low OA may be partially overcome by escalating imatinib dosage where tolerated (Hughes et al, 2008; White and Hughes, 2012).
Motion artifacts may be partially overcome with fast acquired sequences such as FIESTA which produced the highest quality images in our study.
What we can note, however, is that P. cochleariae may have partially overcome this line of plant defense, as polygalacturonase activity can still be detected in its gut contents.
These problems may be partially overcome by adding water-soluble fillers that increase cement porosity and facilitate antibiotic release, and vacuum processing techniques can lead to more homogenous cement compositions [ 9, 43, 46].
However, in several studies investigating novel agents, available data suggest that the poor prognosis conferred by t(4 14) (as well as by other poor-risk cytogenetic abnormalities) may be partially overcome by the newer agents, particularly bortezomib.
Problems of respiratory motion, spatial resolution and immobilization may be partially overcome by the use of PET/CT and fusing the images to the radiotherapy planning CT, or by the use of a dedicated PET/CT simulator.
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