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The controversy on adrenal function in critical illness is further compounded by the allegedly poor relation between protein-bound total and free cortisol involved in tissue effects and feedback, but increases in free cortisol may parallel increases in total cortisol, irrespective of binding proteins [ 5, 17].
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Several possibilities may explain the parallel increases in miRNA and target expression levels.
The growth in the event may parallel a general increase in the awareness of and interest in gluten-free dining options.
These parallel increases may be explained by a common metabolic pathology because type 2 diabetes is an independent risk factor for the development of Alzheimer disease (1, 2).
Taking into account that uric acid is the main determinant of TAS (reviewed in Bartosz 2003), increases in TAS may be associated with parallel increases in plasma urate that also peaked after 12 h running, although the association between TAS and serum uric acid content did not reach significance.
An alternative mechanism responsible for exercise-induced increases in CRP may be the parallel increase in anti-inflammatory cytokines.
This may parallel the reported age-associated increase in suppressive T regulatory cells (Gregg et al 2004).
In parallel, increases in Aβ or other proteolytic fragments of APP at synaptic sites may act to protect vulnerable neurons from glutamate-mediated excitotoxicity [ 46].
Not a huge increase, but the actors and directors will get parallel increases too.
The progressive increase in metformin use may result in a parallel increase in the incidence of associated lactic acidosis.
Therefore, increased firing of the STN under parkinsonian conditions may lead to a parallel increase in glutamate release in the SNc.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com