In the context of VN1203, this robust response may overwhelm the host leading to increases in lung tissue damage, decreased respiratory function and overall increases in pathogenesis linked to fatality.
It is possible that too much intracellular proliferation of Leishmania spp. may overwhelm the host's immune defence prematurely, cause exacerbated disease forms and progression, and thus affect the chain of infection negatively.
Thereafter the combined absence of Perforin-2 in the barrier tissue and in professional phagocytes may overwhelm the host by enhancing the systemic dissemination of the bacteria and, ultimately, leading to multiple organ failure.
A pathogen must evade host innate and acquired cellular and humoral immune responses, replicate at a sufficient rate to overwhelm host clearance mechanisms, and cause tissue injury.
Rainfall rates such as these may overwhelm the capacity of storm drains, resulting in local flooding.
So preoccupied are we with our inner imperatives that the outer world may overwhelm and confuse.
Nevertheless, continued growth of RA contributions may overwhelm vulnerable age groups such as young adults.
Flood of data from new "space fence" radar may overwhelm some satellite operators.
Moreover, traffic from wireless stations mounting denial-of-service (DoS) attacks or infected by a virus may overwhelm the network.
This may overwhelm residents or make them anxious.
