The significant presence of cancer-associated genes as part of the Oct4 transcriptome is a theme shared with ESCs [ 10, 102], suggesting that an Oct4 circuitry may be operating also in cancer cells and providing a molecular link between the regulation of pluripotency and the acquisition of dedifferentiation in cancer cells [ 103- 107].
Aliefs are not propositions; they also may operate according to what RIM and APE call associative processes.
Short-haul carriers also may operate efficiently out of a single hub.
We suspect that this mechanism may also operate in situations of intergroup competition, which also raises the salience of group boundaries.
Interestingly, YC-1 has also been reported to block HIF1α activity [20] and therefore may also operate at a transcriptional level.
As similar deficits are also noted in SAD, analogous pathogenic mechanisms, disturbing specific trafficking/degradative processes, may also operate in late-onset AD.
Urologists may also operate to remove stones that have formed in the urinary tract, and they may perform operations to remove cancers of the kidneys, bladder, and testicles.
Finally, it can be assumed that individuals' health may influence their SOC, i.e., the causality between SOC and health may also operate in the other way around.
Dosage balance may also operate in a positive sense: rather than blocking toxicity, the co-duplication of many interacting genes may aid the development of novel pathways and functions.
Since hypomorphic mutations in RAD51 in mammalian cells also reduce DSB repair by conservative gene conversion and stimulate non-conservative repair by SSA, this mechanism may also operate in humans and, perhaps contribute to the genome instability that propels the development of cancer.
