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By comparing our negative data for resveratrol as CRM with literature data from model organisms and human trials, we conclude that resveratrol may only exert its putative health effects under certain circumstances.
If this is not the case, volume expansion may only exert adverse effects without having any hemodynamic benefit.
As BOK is highly expressed in reproductive organs and granulosa cells, it is not surprising that BOK may only exert its function in limited cell types and/or under particular stress conditions.
Although not an antioxidant, retinol is essential for regulating cell differentiation, and it is possible that it may only exert a notable effect without the overwhelming influence of other major risk factors.
These early risk factors for T1D may only exert influence in the early years and once these susceptible children develop IA, maternal age may no longer be associated with increased IA risk.
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In addition, they suggest that ecSOD may not only exert its effects via its archetypal extracellular localization but may also be present within the cytoplasm exerting influence on O2− levels within the myocyte.
Nonetheless, metoprolol may indeed only exert its central effects leading to a reduction in attack frequency, if taken on a regular basis over several weeks.
Circulating MIF may not only exert its functions by extracellular signal transduction (5) but also by an intrinsic antioxidant property (12, 13, 18, 40).
Therefore, these mesenchymal cells may not only exert local effects within the tumour, but could also represent systemic effectors relevant for the metastatic process by functioning as carrier cells during extravasation of tumour cells and/or 'landscaping' secondary organ sites where circulating tumour cells can home to and form secondary outgrowths.
Besides, the biological consequences of altered protein function may only be exerted under certain environmental conditions.
These data suggest that stromal genetic alterations are either not dominant or may exert an indirect effect on the adjacent epithelium, or that they only exert an effect in collaboration with others to influence the overall process of tumorigenesis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com