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The regional scale analysis is useful because the PCA statistical space is defined by the range of variation in the whole dataset, and thus the broad US-wide comparison may obscure patterns that would be relevant to users at the regional scale.
We chose to work with live birds instead of museum specimens to avoid introducing other sources of variation that may obscure patterns of variability.
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As the cell line intrinsic properties may obscure expression patterns related to PIP gene expression, we appreciated the range of biological variability through unsupervised clustering of the entire gene expression profiles (Figure 2).
We also note that the sheer volume of genomic data that is available in the HP and HM databases, compared to that of the HG may obscure important pattern differences, and that redundancies in epitopes between pathogens may further obscure differences; future iterations of this tool will allow a slight discount or 'weighting' of redundant epitopes.
When presented in isolation for all cancers, it may provide a misleading impression of future mortality burden of cancer overall, and furthermore, it will obscure patterns of mortality by type and by age data within type.
Some regulators and civil rights experts also worry that arbitration clauses can obscure patterns of wrongdoing.
One underemphasized component of pseudocongruence may result from the efforts of researchers to categorize patterns visually - similar patterns may, in fact, not fully coincide, and inferring agreement may obscure the actual patterns and lead to erroneous conclusions.
Since either horizontal transmission or independent infections appear to be common in G. f. fuscipes, genetic data may not be the ideal method to detect any form of CI as these processes may obscure host genetic patterns induced by Wolbachia.
While this method effectively captures mean F0, it may obscure state-dependent patterns of variation.
Using only one sequence per genus may reduce the power of the test, which may obscure a weak pattern; but using only one randomly selected species per sister lineage is unlikely to generate any systematic biases in rates, making this approach conservative for testing an association between rates of molecular evolution and net diversification (see [ 8, 11]).
The cross-cancer analysis that we present also suggests that tissue-specific patterns may obscure detection of underlying pan-cancer epigenetic signals, which are often weak in comparison to competing signatures of cellular differentiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com