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A nucleotide substitution in the DNA that results in an amino acid substitution in the corresponding protein may or may not severely affect the biological function of the protein.
Nevertheless, as misreporting is non differential the deriving underestimation may not severely affect results.
Since TLR2 is involved in Chlamydia-induced TGF-beta, an anti-inflammatory cytokine with an important role in fibrosis, and thus very likely in post-infection tubal pathology, it might explain why CD14 polymorphisms may not severely impact the development of tubal pathology[ 49].
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Moreover, some facilities, for example, dispensaries and clinics have limited capacity to treat severe malaria, and may not refer severely sick in time because of lack of communication.
Even if we may not feel severely stressed, it can be a beneficial practice to engage in both non-spiritual and spiritual coping strategies.
These events may not only severely harm the patients immediately but may also impede the continuation of irradiation and the subsequent tumour resection which may deteriorate disease-free and overall survival.
However, huge simulations have shown that estimation of fixed parameters may not be severely compromised (e.g., [ 13]) even if the assumption of normality of the random effects is violated.
Second, it is also possible that it is the basal activity and metabolic regulation of autophagy that decline during aging, but cytotoxic stress-induced autophagy may not be severely affected particularly in long-lived cells, which are susceptible to the accumulation of oxidative stress.
But the number of jobs reported lost by the Labor Department on Friday was significantly smaller than most analysts had predicted, and the unemployment rate nudged down to 5percentt, raising hopes that the economy may not suffer as severely as once feared.
Similarly, the multiple sclerosis patients were being treated at a multiple sclerosis clinic, and many may not have been severely impaired at the time they were interviewed.
Patients were required to show a minimum level of cooperativeness with study procedures, so the sample may not represent very severely agitated or combative patients with schizophrenia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com