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However, maltose may still be able to bind in the presence of the disulfide, which results in a fluorescence change, but it may not activate enzyme activity due the engineered disulfide bond, which keeps the conformational equilibrium toward the open state.
In addition, recent evidence suggests that although Rheb has a well-described role as a key upstream activator of TORC1, it may not activate TORC2, and in fact may have an indirect inhibitory effect on TORC2 [50].
Alternatively, THz-induced DNA damage may not activate ATM, or may cause its delayed activation.
Whereas pseudowords may partly activate memory circuits for words and morphemes (Wennekers et al. 2006)—as reflected by a reduced activation but a still measurable superior temporal inferior frontal time delay unfamiliar noise sounds may not activate corresponding memory traces.
"We may not activate him for a couple of days," Girardi said.
This latter finding suggests that salmon thrombin may not activate all of the receptors that are targets of human thrombin, although it does appear to activate signals that are sufficient to produce normal rates of activation and aggregation as measured by conventional aggregometry.
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YPR015C was recently identified as one of 100 novel, weakly expressed cell cycle-regulated genes when yeast were grown in a fermentor using minimum medium, indicating that some of the transcriptional factors may be not activated in rich medium [ 11].
Therefore, nSP30-N, which also has amino groups but did not activate CYP3A4, may interact with CYP3A4 differently than nSP70-N does.Next, we investigated the mechanism of the effects of silica nanoparticles on CYP3A4 activity.
Since these two residues are involved in binding the two exchangeable molecules of AMP, this may explain why AMP does not activate the yeast complexes.
Accordingly, in spite of higher fasting-state GCK activity in the presence of P446L-hGKRP, GCK may not be activated to the same extent by increased glucose in the presence of this variant.
These results imply that Wg signaling affects the ASP indirectly that although Wg signaling may not be activated in the ASP, Wg signaling nevertheless plays an important role by down-regulating Dl expression in ASP-associated myoblasts that activate Notch signaling in the ASP.
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