Exact(4)
Figure 1: The introduction of just a -COOH functional group as a strategy may not abolish the CNS activity completely (-COOH is negatively charged at the physiological pH).
75 As such, the unpredictable absorption of these agents may not abolish high peak and low trough LD plasma levels that are associated with the development of dyskinesia.
However this is true only for repositioned drugs for new indications ". Figure 1: The introduction of just a -COOH functional group as a strategy may not abolish the CNS activity completely (-COOH is negatively charged at the physiological pH).
This may also explain why ATP-sensitive potassium channel blockers (e.g. sulfonylurea drugs) may abolish, whereas insulin may not abolish and may even enhance protection afforded by ischaemic preconditioning of the human myocardium [ 7].
Similar(56)
We have chosen a sub-acute time window (7 days) for grafting, since earlier grafting could interfere with spinal shock and edema whereas in the chronic phase detrimental presence of fibrotic tissues may reduce if not abolish expected benefits.
Since RNAi may not totally abolish expression of the gene, this technique is sometimes referred as a "knockdown", to distinguish it from "knockout" procedures in which expression of a gene is entirely eliminated.
However, higher levels of physical activity may not completely abolish the counteracting and detrimental effects of obesity on diabetes risk [ 23].
Single amino acid replacement at either aspartate-86 or −97 (goose numbering) may not fully abolish muramidase activity, as was shown by site-directed mutagenesis [ 56], but likely will reduce enzymatic activity.
It is important to note, however, that while the wac and Dgrip75 mutations are nulls, the lack of either protein may not completely abolish Augmin or γ-TuRC function, respectively.
These results suggest either that the lack of sex chromosome dosage compensation explains a large fraction, but not all, of the demasculinized X; or alternatively, that RNAi knock-down of msl2 in these experiments may not completely abolish MSL-dependent dosage compensation (Hamada et al. 2005).
CEBPα gene mutations may not only abolish the proliferation suppressive function of the full-length p42 CEBPα, but also correlate with the expression of lymphoid markers in AML cases (Wouters et al, 2008), suggesting that myelo-lymphoid lineage ambiguity could be achieved in both lineages by converging routes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com