Alternatively, PPM-1 may negatively regulate a positive regulator of PMK-3, such as UEV-3.
In consideration of the CK2-regulated XRCC1 phosphorylation for its stability, we presumed JWA may negatively regulate XRCC1 expression through CK2-regulated XRCC1 phosphorylation machinery.
Some genes related to the cell wall were down-regulated by gs3, implying that down-regulation of these cell wall-related genes may negatively regulate cell wall formation.
Another member, PCN, may negatively regulate secondary vascular cell differentiation (Kim et al. 2005; Du et al. 2011).
These data suggest that the N-terminus has no enzymatic activity but may negatively regulate DGAT1 activity.
As srGAP3 can negatively regulate neuronal differentiation of Neuro2a cells, we speculate TET1 may negatively regulate Neuro2a cells differentiation via modulating the expression of srGAP3.
Therefore, we suggest that SPL5 may negatively regulate the biosynthesis of tryptophan and serotonin, which, in turn, affects defense responses in rice.
Instead, these proteins may negatively regulate NF-κB activation.
One major question is how N-cadherin interaction may negatively regulate cell proliferation and survival.
From these results, we suggest that both Gli3 and Alx4 genes may negatively regulate Hh signaling.
It nevertheless remains a possibility that these proteins may negatively regulate DNA replication.
