Equipment and/or experimental methods and procedures may need prior validation before use within a study.
We admit that our recommendations for thyroid management in patients under sunitinib may need further validation in a prospective randomized trial.
The measures of I, A and P were derived and may need further validation and the number of items in the P measure was small and may not have fully covered the domain.
Both of the aforementioned studies suggest that TYMS may be a suitable marker of sensitivity to pemetrexed-based chemotherapy in patients with NSCLC, although one of them indicates that the prognostic value of TYMS protein expression may need further validation.
However, the application of molecular tests to known grade 1 and grade 3 breast cancers in the treatment decision-making process may need further validation and confirmation of any additional prognostic value and cost benefit.
They can be used to map crude overviews down to intricate details (which may need statistical validation), allowing for a systematic interpretation of the entire variance of large datasets (Fig. 5).
Clearly, these low-titre positive samples from grossly normal animals are very close to the limit of detection for this assay and may need further validation in the context of larger sample numbers.
The findings of molecular marker expressions may need further validations of mutation analysis.
Automatic thresholding or maximum gray-scale thresholding will need validation because they may be too variable to achieve consistent results clinically.
