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The slow release was advantageous to maintain effective blood concentration of the drug which may necessitate less frequent drug administration [ 39].
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The cost-effective treatment of CDI may necessitate the appropriate use of less-expensive metronidazole.
We recognize that extenuating circumstances may necessitate allocation of scare resources and less optimal strategies put in place.
Although the cost-effective treatment of CDI may necessitate the appropriate use of the less-expensive metronidazole, vancomycin should be administered in cases expected to become severe or life-threatening.
Higher SLE prevalence in racial/ethnic minorities such as American Indian/Alaska Native (AI/AN) people, often residing in areas with less access to rheumatologists, may necessitate diagnosis and management of SLE by primary care providers (PCP) in some cases.
The rate and severity of change in physiological functioning are important to consider, for example less severe but rapid changes may necessitate hospitalization [ 93].
While this can aid in 'normalizing' the overall Tm of less GC-rich sequences, synthesis of longer oligodeoxynucleotides (ODN s is often required, and may necessitate costly purification.
It is less easy to attach accurate costs to individual items of health care, and this may necessitate separate research into health-care costs in the country or region in question [16].
The problem lies in identifying those patients in whom tissue hypoxia is less overt, who may in fact have 'normal' hemodynamic parameters, and augmenting D O2 in such patients may necessitate reaching 'supranormal' values.
Such analysis will help to identify when informal intelligence is less likely to be influenced by potential bias or when significant gaps in epidemic data likely exist that may necessitate supplementation with other sources.
The injury may necessitate arthroscopic surgery this summer.
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