Our findings further establish that although the end result of mTOR inhibition is a global decrease in protein synthesis, differential inhibition of mTOR signal transduction may distinctly modulate translation of specific subsets of mRNAs that control the key cellular processes responsible for cell fate.
Finally, we demonstrated that microRNAs may modulate GNG7 translation.
Finally, it is also possible that local protein synthesis in C-fibers may be under the control of signaling molecules other than mTOR, and there is evidence that extracellular regulated kinase (ERK) may modulate local translation of mRNA in C-fibers (Price and Geranton, 2009).
However, HuR has also been shown to modulate translation of a number of targets [35], [36], [37].
Alternatively, a selective inhibition of translation could be coupled to alternative AID mRNA splicing, particularly as recent reports showed that splicing factors could modulate translation initiation 26.
Since cellular factors may modulate chimeric GBV-B/HCV RNA translation, we next assayed translational efficiencies of the various chimeric 5'NTRs in cell culture.
A number of mRNA un-translated regions, particularly at the 3' end, may modulate mRNA maturation, transport, turnover and translation for example and protein turnover may also vary [ 4].
This interaction may modulate a selection of cellular activities including gene expression, cell proliferation, translation, cell signaling, membrane stabilization, and ion channels [ 13– 13].
Induction of LTP and LTD in the CA1 region of the hippocampus involves numerous protein kinases and/or phosphatases [13], [18], which are believed to be critical for the translation of electrical activity into persistent subcellular alterations that may modulate synaptic strength.
The potential translation of proteins bearing only the N-terminal MIS prodomain may modulate the functions of other TGF β family members in different tissues.
