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Further studies on the mechanisms of this association and on possible interventions which may modulate this risk are warranted.
We examined the hypothesis that bacteria and viruses may modulate this heterogeneity and that interactions between bacterial and viral infection may affect changes in airway bacterial load and the clinical features and inflammatory responses of exacerbations in patients with COPD.
We speculated that, NR2B-bound CaMKII might acquire properties that very well may modulate this switch.
Moreover, Rtn4r may modulate this aspect of NMDA hypofunction on early brain wiring.
These data indicate that SERCA2a can target the calcineurin/NFAT pathway and may modulate this pathway through its effect on intracellular Ca2 needed for calcineurin activation [30].
AVA may modulate this action.
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The proximity of Rpb4/7 to the flexible clamp and its influence on clamp position in low-resolution structures suggest that the heterodimer may modulate the position of this flexible module [ 84, 85].
Several cases of PD caused by repeat expansion mutation have been described in African-Americans, and it has been suggested that genetic background may modulate the expressivity of this mutation [17].
Flavonoids and other phytochemicals can bind to functionally diverse cellular targets and this may modulate the activity of a large number of downstream genes (4). Figure 4 depicts some conceptual strategies used to block the imbalanced production of ROS.
To determine whether the promoter polymorphism may modulate the expression of this gene, dual luciferase reporter gene assays and real-time PCR analysis were performed and the results showed that the T allele was associated with decreased promoter activity and may down-regulate the expression of UBAC2.
That subspecies are not reflected in major phylogeographic divisions is not surprising in light of patterns exhibited by many other taxa, but this does not preclude the possibility that local adaptation may modulate the evolutionary trajectories of this species.
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CEO of Professional Science Editing for Scientists @ prosciediting.com