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Increased mucosal IL-12, IL-23, IL-1β and IL-6 were indicative of a cytokine milieu that may modulate subsequent T-cell mediated immunity.
Likewise, the association of leptin and IL-6 adds another tier to the wealth of data implicating a tight relationship between these cytokines, in particular highlighting how basal leptin may modulate subsequent IL-6 levels.
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TLR stimulation as PC initially induces a transient up-regulation of inflammatory mediators, which in turn may modulate the subsequent inflammatory response and desensitize the heart to I/R [ 11].
Interestingly, inflammatory signals are important epigenetic modifiers [27], which raises the possibility that the tissue trauma associated with pregnancy loss, or even menstrual events between pregnancies, may provide cues that dynamically modulate subsequent decidual responses in the endometrium [9].
Here we show that motor learning can modulate subsequent activity within resting networks.
Combined, the results suggest that spontaneous activity in the dentate periodically induces a sharp wave and thereby may modulate the amplitude of subsequent potentials in CA3.
Given the prominent role of the local cholinergic system in mediating DA release in this region, varenicline may modulate dopaminergic activity and subsequent drinking behaviours through nAChRs in the NAc.
We hypothesized that exposure to multiple injuries may modulate the innate immune response and the subsequent outcome of infections.
Taken together, these results suggest that while AR activation may modulate phosphorylation of eIF2 α and the subsequent activation of its effectors, this pathway is not involved in AR-mediated inhibition of autophagy.
However, it is possible that TLRs may modulate the latter part of the response or modify the response to a subsequent proinflammatory challenge.
In particular, subsequent metabolism (e.g., sulfation and glucuronidation) and transport of OH-PCBs may modulate the atropisomeric enrichment of OH-PCBs in vivo; however, the atropselectivity of these biological processes has not been investigated to date.
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