Prolonged high expression of ALKBH2 also indicates that it may modulate the responsiveness to Ph-PDT.
These polymorphisms may alter transcriptional activity and thus VDR abundance and may modulate cellular responsiveness to 1,25(OH)2D.
A similar phase I trial reported a CR of 25% with tamoxifen and tipifarnib in a heavily pretreated hormone resistant patient population, further supporting preclinical data that FTIs may modulate endocrine responsiveness [ 42].
As GR polymorphisms may modulate GC responsiveness of the immune system, we hypothesize that polymorphisms in the GR gene, which are accompanied by relative GC hyper- and hyposensitivity, are associated with a decreased or increased susceptibility to develop RA, respectively.
The observation that light had a differential effect on mRNA levels at different times of day suggests that the pineal clock may modulate photo-responsiveness itself as a function of circadian time, such that light has a greater effect at a time when it is normally present as an exogenous stimulus.
These data suggest that the GHRd3 polymorphism, shown to modulate responsiveness to GH using in vitro cellular models (2), may be associated with activation of different GH-signaling pathways, dependent on the level of endogenous GH present in the circulation.
DOI: http://dx.doi.org/10.7554/eLife.04851.010 Due to the enhanced expression of CD25 in the absence of TGF-βRII signaling, we questioned whether TGF-β may modulate the IL-2 responsiveness of early effector CD4 T cells.
Calcium channel antagonists, when used to treat hypertension, may modulate baroreflex function and vascular responsiveness to endogenous vasoconstrictors.
On the other hand, in heparin-resistant patients undergoing cardiac surgery with cardiopulmonary bypass, there are recent data suggesting that normalizing AT during extracorporeal circulation may modulate thrombin generation, decrease levels of fibrin monomer and D-dimer [ 25], restore heparin responsiveness, and then promote therapeutic anticoagulation [ 26, 27].
Therefore, we hypothesized that PHGDH may modulate autophagy in ECSLCs.
