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The genes encoding enzymes involved in glutathione (GSH) metabolism may modulate responses to antimalarial drugs, but the role of most of them in antimalarial drug resistance has scarcely been investigated.
Evidence that gut-resident bacteria play a role in shaping immune defences form the basis for the hypothesis that probiotics may modulate responses to infection or vaccination.
Interestingly, our data also suggest that the cellular response to EGF is bypassed in the absence of NHS or suppressed in the presence of NHS, implying that NHS may modulate responses to extracellular signalling.
The functional implication of these mechanisms is that the the Par-complex may modulate responses that include secretion of cytokines in addition to the well-known tight junction opening (Pasparakis, 2012), an as yet unsuspected possible mechanism in chronic inflammation.
The unexpectedly high H. pylori seropositivity rate in this seriously ill cohort raises the possibility that under Intensive Care conditions H. pylori infection may modulate responses to illness and injury, with consequent clinical implications.
To test the hypothesis that a common pathway may modulate responses to stimulation of the TLR4 and FcεR1 receptors, BMMC were incubated with DNP-IgE (50 ng/ml), prestimulated with LPS (10 ng/ml or 100 ng/ml) for 18 hours, and then stimulated with antigen (20 ng/ml).
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Sex hormones may modulate response to infectious agents [ 7].
However, p53 may modulate response to radiation damage in the G1 phase of the cell cycle through mechanisms independent of p53-mediated transcriptional activation of p21 and cell-cycle arrest (Mazzatti et al, 2005).
Clustering of gene sets was performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID; http://david.abcc.ncifcrf.gov/; [ 42]) to identify potential gene pathways and key functional groups that may modulate response of bacteria to HU or knock out of ybeY.
This weakness is especially relevant in light of new knowledge from animal studies, which suggest that endocrine-disrupting chemicals may modulate response to dietary intake (Bhathena and Velasquez 2002; Enan et al. 1996), disrupt the hypothalamic pituitary axis (Rubin et al. 2001), and possibly increase risk for childhood obesity (Newbold et al. 2007).
No role for progranulin has been identified in colorectal cancer, but sortilin has been demonstrated to be expressed by HT29 human colorectal cancer cells and may modulate response to nerve growth factor in these cells (Martin et al, 2002; Navarro et al, 2002; Morinville et al, 2004).
More suggestions(15)
may suppress responses
may elicit responses
may provoke responses
may reduce responses
may predict responses
may sway responses
may decoy responses
may mask responses
may yield responses
may give responses
may be responses
may facilitate responses
may confer responses
may exhibit responses
may represent responses
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com