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In addition, ionotropic glutamate receptor antagonists may modulate other sub-circuits in the olfactory bulb or the feedback from higher brain regions onto interneurons (Fig. 1).
Perhaps myocytes coordinately regulate the expression of TrpC3 and other Trps, such that knockdown of TrpC3 in the absence of other stimuli may modulate other Trp channels which regulate cell size.
NK cells and γδ T cells may have direct effector functions or may modulate other immune responses [1], [2], whilst naturally-occurring CD4+CD25high FOXP3+ regulatory T cells may be suppress immunity [3], [4], [5].
However, ISRIB may modulate other post-translational modifications that impinge on the activity of eIF2B.
In theory, testosterone may modulate other aspects of Ca2+ handling in the cardiomyocyte.
We next sought to determine if FUdR may modulate other fertility signals to confer thermotolerance.
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Furthermore, although the association between PNPLA3 genotype and adiponectin was independent of steatosis severity in patients with NAFLD, our results does not exclude that PNPLA3 may modulate adipose tissue indirectly by regulating the secretion of hepatokines such as fetuin [ 40], and that it may also modulate other pro-inflammatory molecules such as resistin and ICAM-1 [ 26, 41].
It is possible that USP19 may modulate yet other ligases for p27Kip1 that have not been uncovered.
The mechanism of p53 activation by quinacrine and its ability to modulate other signaling proteins may minimize the toxic side effects seen with treatments using DNA-binding platinum agents, making it potentially a desirable anticancer agent.
Furthermore, overexpression of the receptor may have modulated other components that could affect β-catenin stability.
On the other hand, ESET may modulate apoptosis via other pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com