Sentence examples for may modulate methylation from inspiring English sources

Recent studies suggest it, like DNA methylation, can regulate the expression of genes involved in certain cancers, and that it also may modulate methylation levels.

The translocations resulting in the expression of a fusion protein may modulate DNA methylation patterns via aberrant repression or activation of downstream genes.

Further bioinformatics analyses indicated that these loci may modulate corresponding gene methylation status.

This preferential remethylation of specific loci suggests the involvement of factors which may modulate the cellular methylation efficiency after replication.

Changes in ROS may modulate sperm DNA methylation and chromatin structure, ultimately influencing regulation of imprinted genes important in growth and development; or other genes, such as those responsible for maintenance of genome stability, altering DNA damage responses and repair mechanisms.

In invertebrates, genes belonging to dynamically regulated functional categories appear to be less methylated than "housekeeping" genes, suggesting that DNA methylation may modulate gene expression plasticity.

Methylation at alternative promoters or splice sites can affect transcript variants expression, whereas enhancer methylation may modulate gene expression (Jones, 2012).

In addition to direct effects, Lys methylation also may modulate protein function through cross-talk with other PTMs.

One possibility is that an altered local H3K36 methylation state may modulate the function of proteins that normally "read" the mark.

Reversible RNA methylation involving Fto suggests that dynamic methylation states of mRNA or miRNA may modulate protein expression and cell status, analogous to reversible DNA and histone methylations.

We found and confirmed aberrant DNA methylation alterations in a number of CGIs, suggesting that DNA methylation is associated with cardiac function and may modulate phenotypic characteristics of idiopathic DCM.