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In our previous study, in silico locus control analysis identified lncRNA ESCCAL-337 (chr3:171506370-171528740) and ESCCAL-356 (chreverse500-1567142, reverstrandand) may modulate lipid metabolism genes contributing to esophageal cancer development [ 34].
Importantly, lycopene, an exogenous antioxidant, may modulate lipid profile disturbance and, potentially, be protective against atherosclerosis in HD patients.
As candidate gene on Chr 12 we suggest Rsad2, which may modulate lipid droplet contents and lipid biosynthesis, and Colec11, which may play a role in apoptotic cell clearance and maintenance of adipose tissue.
Further, high-dose vitamin E as an add-on therapy to riluzole in ALS did not extend survival, although improvement in the rate of deterioration of function was suggested for vitamin E. 97 Another group of antioxidants associated with a lower risk of ALS is polyunsaturated fatty acids, 92, 98, 99 which may modulate lipid metabolism, oxidative stress, and inflammatory processes.
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Finally, helminthes may modulate host lipid metabolism, and may be responsible for lower blood cholesterol levels in parasitized humans [60].
In particular, it has been hypothesized that a potential pathway for Aβ toxicity may lie in its ability to modulate lipid membrane function.
Second, linagliptin increases GLP-1 and GIP levels which may provide beneficial cardioprotection; experimental and clinical data suggest that GLP-1 elevation can positively modulate lipid metabolism [ 26], reduce infarct size and improve cardiac function [ 26, 27].
Lipid storage may also be affected in some of these diseases since Atlastin-1, REEP1, Spartin and Seipin modulate lipid droplet structures (Renvoisé et al. 2012; Klemm et al. 2013; Falk et al. 2014).
Statins, fibrates and TZDs modulate lipid and glucose metabolism.
COMT metabolizes catecholamines, which are known to modulate lipid mobilization[49].
We hypothesized that, using long-term dietary intervention studies, dietary fatty acid composition may modulate gene expression and lipid metabolism in the intestine, and that especially EPA and DHA may stimulate expression of genes involved in lipid catabolism.
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Justyna Jupowicz-Kozak
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