Although not the focus of the present study, endocannabinoids may also modulate levels of activity of thalamic neurons via activation of CB1 receptors.
The influence of other factors that may modulate cortisol levels, such as age, pubertal stage, body mass index (BMI), adverse life events [ 37], and internalizing behavior, was also evaluated.
Finally, this approach may not detect complex, non-additive genetic mechanisms, such as complex gene-gene or gene-environment interactions that may modulate biomarker levels.
This suggests that miR-221 regulates the expression of p85α and that this miRNA may modulate p85α levels during the aging process.
For instance, vasoactivity has been reported for some PARPi that may modulate the levels of hypoxia within tumours [ 13, 14].
Recent studies suggest it, like DNA methylation, can regulate the expression of genes involved in certain cancers, and that it also may modulate methylation levels.
Taken together, these data strongly suggests that endogenous STAT3 does indeed become activated and induces a transcriptional programme that may modulate the levels of I/R-cell death in cardiac cells.
As a result of this association of the polymorphic allele with distribution of body fat storage, we suggest that genetic variability in the ADIPOQ gene may modulate the levels of sAdiponectin.
In addition, both acute and chronic stress may modulate BDNF levels and structural plasticity in a variety of brain areas, including the hippocampus, prefrontal cortex, and amygdala (Calabrese et al. 2009; McEwen 2008; Pizarro et al. 2004).
