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The complexes may modulate genes by either the classical ERE pathway or via protein-protein interactions.
The SERM – ER complex can recruit coactivators and corepressors, and these complexes may modulate genes by different pathways.
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Epigenetic changes refer to heritable changes that may modulate gene expression without affecting DNA sequence.
Further P. falciparum may modulate gene expression in bystander erythroblasts and thus influence pathways of erythrocyte development.
Since cells return to cycle normally only after 24 h, such protein-protein interactions may modulate gene expression specifically in "white" medium.
While RNA molecules in the sperm chromatin may modulate gene expression in the progeny [21], paternal inheritance of epigenetic information in the form of CpG methylation patterns that in turn direct the establishment of site-specific non-CpG methylation may be but one more example in this class of non-Mendelian heredity.
As well as miRNAs may modulate gene expression, the opposite may also be true.
The profibrotic and hypoxic environment associated with SSc may modulate gene expression profiles of circulating monocytes.
Several mechanisms have been proposed how MeCP2 may modulate gene expression by association with repressor or activator proteins.
In invertebrates, genes belonging to dynamically regulated functional categories appear to be less methylated than "housekeeping" genes, suggesting that DNA methylation may modulate gene expression plasticity.
These plants may act on different targets in signal transduction pathways that may modulate gene expression, cell cycle progression, cellular proliferation, and/or apoptosis [ 3, 4].
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