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This heterogeneity may modify gene expression levels depending on the proportion of each cell type.
Alternatively they may modify gene expression; they and their eicosanoid and docosanoid metabolites are recognised ligands for PPAR.
Another way TEs may modify gene expression is to sensitize a gene to be under epigenetic control.
A protease antiprotease imbalance may modify gene expression profiles in LE cells to overcome the extracellular stimuli.
Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family – RARα, RARβ, and RARγ – but shows relative selectivity for RARβ and RARγ and may modify gene expression.
Furthermore, variations in iron concentration may modify gene expression in the cell through the iron regulatory proteins Irp that bind to the iron responsive elements (IRE) located in their target genes UTRs.
Similar(52)
Response regulators may modify genes expression by direct binding to the genes promoters or by action on other regulators that, in turn regulate target genes expression [16], [33] [36].
This observation can be explained by the fact that many mutations may or may not modify gene functions but do not affect their expression.
Their presence may therefore modify gene neighbourhood in a non-random, non-selective manner.
The chromosomal insertion of a Ty element can result not only in the loss or alteration of gene function, but may also modify gene expression levels.
In addition, early environmental factors acting during embryonic, fetal, or early postnatal periods may also modify gene expression [ 12, 16, 23].
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