One plausible reason for this is that epistatic interactions between alleles inherited from distinct subspecies (castaneus, domesticus, and musculus) may severely misregulate gene expression and homeostasis.
Additionally, we show that although the truncated MeCP2 protein in these mice localizes normally to heterochromatic domains in vivo, histone H3 is hyperacetylated, providing evidence that the chromatin architecture is abnormal and that gene expression may be misregulated in this model of Rett syndrome.
In this model, we would expect that contiguous regions of DNA, containing one or more genes, may be misregulated.
Spermatogenesis, a process tightly controlled by hormonal interactions with the hypothalamic-pituitary-gonadal axis [30], may be misregulated due to improper interactions with hormones and receptors.
These may reverse misregulated epigenetic states and be implemented in the treatment of cancer or other diseases, e.g., neurological disorders.
PTEN levels are controlled by miR-26A, which is amplified in GBM. - The current thinking is that in addition to well-established PTEN somatic mutations, PTEN levels are controlled by miRNAs, which may be misregulated in tumors.
This tissue-specific splicing is responsible for proper neural cell differentiation and neurotransmitter signaling that may be misregulated to allow stem-cell like proliferation to form brain tumors [ 23- 27].
Because MOP1 is known to be an epigenetic regulator of genes that demonstrate changes in nucleosome distribution during regulated changes in gene expression, nucleosome distribution may be misregulated in mop1 1 mutants due to the disruption of a MOP1-mediated chromatin-remodeling event at the TSSs of Yab15 and Lg1.
In biochemistry, it may be protein folding.
