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We submit that further studies into mechanisms underlying the regulation of CD44 palmitoylation and lipid raft containment may merit evaluation as a novel target to reduce breast cancer metastatic spread.
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These in vitro observations suggest that combinations of proteinase inhibitors, particularly of uPA/plasminogen activation and MMPs, may merit clinical evaluation as potential antimetastatic therapy for breast cancer.
This clinical variable was not statistically significant in our study perhaps due to the low power and may merit further evaluation.
In light of these findings, the combination of PARP and HDAC inhibitors may merit further clinical evaluation in patients suffering from TNBC.
Nevertheless, healthy women aged 65-74 years old had an annual stroke rate of 1.9%, which may merit anticoagulation and evaluation of subtler risks such as absolute levels of blood pressure, whether the patient is aged closer to 65 years or to 75 years, and consideration of other risk factors beyond those in the risk stratification schemes in order to decide on optimal treatment.
However, some elements of the intervention and the need-based approach to developing 'locally customised' services may merit further examination and evaluation.
This may merit further study.
Potential limitations may merit consideration.
This may merit further investigation.
This finding may merit further research.
Two additional issues may merit specific consideration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com