Sentence examples for may mediate toxicity from inspiring English sources

For example, amyloid-beta may mediate toxicity by increasing Drp1 function and producing excessive fission.

Excessive ROS production may mediate toxicity by affecting other processes, such as mitochondrial dynamics and mitophagy, and these may not be effectively targeted by current pharmacological methods.

Because ambient UFP contain organic carbon and other chemical species that may mediate toxicity, it is possible that the vascular effects of ambient UFP may be greater than for the elemental carbon UFP used in this study.

A constitutively high level of p62 under pathological conditions leads to the accumulation of damaged mitochondria and subsequent reactive oxygen species production [ 29], and the accumulation of p62 after autophagy inhibition causes a delay in the clearance of short-lived ubiquitin-proteasome system-specific substrates, like p53, which may mediate toxicity [ 30].

Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure.

First, SMF-1 may mediate Mn toxicity subsequent to Mn uptake at the apical membrane of the intestine, transporting Mn from endocytic compartments to the cytosol.

Both are markedly hyperosmotic, in the range of the complete KYWJ formulation, and their osmolality may mediate the toxicity.

The function of LRRK2 remains largely elusive but G2019S mutations enhance its kinase activity, which may mediate neural toxicity [ 72].

There is in vitro and in vivo evidence to suggest that epigenetic alterations may mediate arsenic toxicity, as recently reviewed by Reichard and Puga (2010) and Ren et al. (2011).

The list of known and potential toxicants is limitless, and part of the role of this review is to alert domain experts to the likelihood that iron, and dysregulation in iron metabolism, may mediate the toxicity of such molecules (and thus that its chelation may be important, under both acute and chronic conditions, in assisting resolution of the toxicity).

The positive charge, however, can mediate toxicity through interactions with blood components and cell membranes.