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Glutamatergic dysfunction may mediate some of these symptoms.
Reduction of food intake associated with hyperleptinemia may mediate some of the vascular effects of leptin.
ILK may bridge RhoT1 to some component(s) of the adhesion complex, which may mediate some modifications on RhoT1 that in turn inhibit its association with TRAK2.
Given the role of PcG complexes in development and the changes in ubiquitination levels observed in Scl-/ cells, we reasoned that RYBP may mediate some of SCL-regulated repression mechanisms.
The stronger differential drug effects in the nasal spray as compared with the cigarette smoking sessions, suggest that nicotine itself may mediate some of the effects on improvement in spatial processing or memory and verbal recall.
Preferential fusion of vesicular cargos with different plasma membrane domains may mediate some polarized distribution as well.
In addition, pathway analysis suggests that the ExEn may mediate some of its functions through a non-classical MAP Kinase signaling pathway downstream of TAK1.
However, we cannot rule out the possibility that USP19 may mediate some of its effects on growth through androgen receptor dependent pathways.
Interestingly, ΔDQ/A53T ASYN was significantly less toxic than A53T ASYN, suggesting that CMA targeting may mediate some of the aberrant effects of A53T ASYN.
We therefore suggest that Rac3 activation is promoted in part by the ABD of βI-spectrin and may mediate some of the effects of endogenous spectrin on postsynaptic structure and function.
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Therefore cadmium may mediate some of the effect of smoking on neurocognitive performance.
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