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Moreover, modulation of anti-apoptotic proteins by TIMP-1 in human neurons suggests that different domains of the TIMP-1 protein may mediate several separate signaling pathways.
Thus, TERRA may mediate several crucial functions at the telomeres, a region of the genome that had been considered to be transcriptionally silent.
Furthermore, based on the variable functions of the regulating genes, intragenic L1s may mediate several cellular phenotypes and are associated with the genome-wide gene expression observed in several diseases.
However, the possibility that non-histone substrates and/or non-enzymatic activities (such as structural functions in multi-molecular complexes) of HMTs and HDMs may mediate several biological actions of these enzymes is also slowly emerging (Huang and Berger, 2008).
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FcγR can mediate several mechanistically distinct uptake processes.
These observations suggest that neurotrophins may mediate hematopoietic responses to several clinically relevant conditions.
Several mechanisms may mediate the effects of alcohol on DNA methylation, including reduced folate levels and inhibition of key enzymes in one-carbon metabolism that ultimately lead to lower SAMe levels, as well as inhibition of activity and expression of enzymes involved in DNA methylation (i.e., DNA methyltransferases).
Several factors that may mediate the effects of stimulant medications on sleep have been identified.
A growing body of evidence suggests that several pathophysiologic pathways may mediate the toxic effects of glucose fluctuations.
Then, we studied the associations of the rs1229984 A-allele with cardiovascular biomarkers from several pathways that may mediate the effects of alcohol on cardiovascular events.
Background: No studies have examined the association between cumulative low-level lead exposure and the prospective development of electrocardiographic conduction abnormalities, which may mediate the association between lead and several cardiovascular end points.
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