Several CARD15 polymorphisms exist: CARD15 (2936insC) may mediate responses to LPS in AA CD [ 38].
This indicates that miR395 mediates not only plant response to sulfate deficiency but also may mediate responses to other nutrients that are imbalanced under abiotic stress conditions.
We hypothesize that some members of the OBP and CSP families may play general physiological roles as carriers or may mediate responses to ligands that are important for metamorphosis and development.
Taken together, we identified a large set of signal transduction components that likely orchestrate a rapid and general response to a wide range of external stresses, but also a large set of signaling components that may mediate responses more specific to plant-herbivore responses.
We identified a set of signal transduction components which likely orchestrate a rapid and general response to a wide range of changes, but also a set of signalling components that may mediate responses more specific to nematode trait deterioration (examples are highlighted in Table 1).
Insulin and TGF-beta signaling may then mediate response to long-term environmental changes, such as long starvation periods, whereas serotonin could also control responses to short fasting intervals.
The increase of cutin and wax may also mediate responses to herbivores.
Furthermore, as breast cancer tumour cells, such as MCF10A and MDA-MB-231, express TGF-β themselves [ 18, 30], we cannot exclude that human tumour cells may also mediate responses in the zebrafish embryos in an autocrine manner.
We used RT-PCR and pharmacology to identify candidate ion channels that may mediate this response.
However, it appears that each of the mechanisms may mediate a response to particular signals.
