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The expression of Fli1 in different cell types may mediate pathological effects that contribute to the multifaceted role of Fli1 in SLE.
In this review we have shown examples of the ways in which platelet secretion is essential for sustaining haemostasis and ensuring an adequate response to injury, but also how the same mechanisms may mediate pathological responses.
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It has been shown that tau may mediate critical pathological effects downstream of A β. Nevertheless, how extracellular A β and intracellular tau pathology is functionally connected remains unclear.
(1) Insulin shared potential control over genes forming the most robust networks under conditions of gain and loss of synchrony (Figure 3), suggesting that deregulation of this homeostatic modulator may participate in mediating pathological changes in depression.
Increasing evidence has demonstrated that ADAM10 is intimately linked to inflammation and may mediate inflammation-related biological and pathological processes [ 33- 35].
Consistent with this hypothesis, data from previous studies indicate that activation of MEF2C may mediate myocardial adverse events invoked by pathological stress[8].
It is clear that early detection of AD will be facilitated through continued investigation of the relationship among the behavioral manifestations of geriatric depression, the brain changes associated with the AD pathological process, and factors that may mediate this association.
Since SUMO modification participates in the regulation of multiple protein functions, repression of sumoylation may mediate a number of NO-related cellular events and pathological processes.
Some experts believe that they may mediate the effects of other cannabinoids.
Both moieties may mediate atherogenicity.
High-glucose environment may mediate these findings.
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