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Interestingly, the activation of platelets at remote sites may mediate lung injury, as shown in mesenteric ischaemia/reperfusion models [206].
This may be important knowledge as inflammatory mechanisms related to coagulation activation, such as hyaline membrane formation and microvascular thrombosis, may mediate lung injury [ 2, 3].
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The above findings suggest that AEG-1 may mediate the metastasis of lung carcinoma through the regulation of EMT.
Furthermore, promoter methylation of HER2 may mediate chemo resistance in breast and lung cancers 48, 49.
Our previous work on breast cancer and the current data from lung cancer suggest that USP33 may mediate Slit signaling in different cancer cells through different mechanisms.
The fact that expression of Bcl-xL blocked the apoptotic effects of the adenovirus in lung injury suggested that Bcl-xL may mediate the role of STAT3 in the regulation and survival of the respiratory epithelium [ 13].
To validate our computational prediction that NRF2 may mediate tumor cell survival in response to arsenic, we generated lung carcinoma cells that were deficient for the expression of NRF2.
A parameter of central importance that may mediate acute and late-occurring disease and treatment-related toxicity in lung cancer survivorship is cardiorespiratory fitness.
Finally, the inconsistent association between asthma and gene expression levels in blood or lung cells from older children and adults suggests that genotype effects may mediate asthma risk or protection during critical developmental windows and/or in response to relevant exposures in early life.
In turn, decreased hyperinflation may mediate improvement in exercise endurance by delaying the attainment of a critically high inspiratory lung volume [ 22, 23].
Local production of AII in the fetal lungs has been shown to promote maturation of pulmonary structure, including vascularization and airway branching (49, 50), and may mediate, in part, some of the beneficial effects of antenatal synthetic glucocorticoids on the developing lungs.
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