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A number of other nucleases may mediate DNA cleavage 3′ to the ICL, including MUS81-EME1, XPF-ERCC1, and SLX1-SLX4, thus excising the damaged region.
Here we discuss how competence induced pili, either by pilus retraction or by a transient pilus-related opening in the cell wall, may mediate DNA uptake in S. pneumoniae.
In consideration of the dual enzymatic activities of sirtuins, early models predicted that the deacetylase activity of sirtuins may function to regulate gene expression, whereas the mono-ADP ribosylation activity may mediate DNA repair [ 58].
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In our DNA binding assay, BSCTV C4 was shown to bind both dsDNA and ssDNA in vitro, which provide us a clue that BSCTV may bind its own viral DNA and may mediate viral DNA transport in certain stages of virus movement.
This result suggests that BSCTV C4 is a nuclear shuttle protein and may mediate viral DNA to move between the nuclear and cytoplasm.
Moreover, recent reports suggest that plant miRNAs can also mediate DNA methylation [11], [69], which adds yet another dimension by which the enriched sRNAs may act.
Ku and DNA-PKcs can mediate DNA synapsis [44].
SH2 domains may mediate functional interactions with DNA binding proteins.
These findings suggest that the interaction of NFI with nucleosomal DNA may mediate chromatin domain barriers at natural genomic locations.
Of note, upregulation of H2AX after NCS treatment preceded that of ROS, raising the possibility that H2AX may mediate ROS induction after DNA damage.
We therefore performed the first analysis of RAD21 in a cohort of fully characterized familial breast cancers and investigated potential mechanisms that may mediate RAD21 levels, including DNA copy number and reduced expression of targeting microRNA.
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