Sentence examples for may mediate distinct from inspiring English sources

These genes may mediate distinct aspects of the process, from intracellular signaling (such as hypodermal-specific transcription factors) to extracellular execution (such as cuticle-digesting proteases).

Menin is phosphorylated at two Ser residues, Ser543 and Ser583, and it is possible that post-translational modifications may mediate distinct cellular functions [26].

Further studies are underway to identify the mechanisms by which PS2 regulates microglia behavior as well as to determine whether PS1 and PS2 may mediate distinct roles in other neural cells or inflammatory cells outside the CNS.

Furthermore, it was recently demonstrated that murine NKT cells from different organs may mediate distinct functions [66], raising the possibility that naïve-like NKT cell subsets may be recruited to different organs where they can undergo divergent effector function programming into distinct effector subsets.

Tissue-specific expression and co-expression of receptor subtypes suggest that ER homodimers and heterodimers may mediate distinct hormone responses [ 12- 15].

The two major substrates IRS1 and IRS2 may mediate distinct pathways in insulin signaling, and they are not functionally interchangeable in many insulin-sensitive tissues [ 43– 43].

Structurally, CCL21 differ from CCL19 in that it has an extra 32 amino acid C-terminus of basic amino acids that may mediate the distinct binding of CCL21 to other molecules (11, 12).

It is therefore anticipated that the Grb2- and Shc-specific docking oncoproteins, and Tpr-Met may prove, upon further analyses, to mediate distinct signaling pathways, and therefore specific cancer processes in IECs.

Conversely, a given growth factor receptor can employ distinct signalling effector pathways to mediate distinct cellular responses.

These results together with the lack of intracellular colocalization with CtxB (below) suggest that recognition of different glycolipids (in this case GD1a vs. GM1), perhaps in combination with membrane proteins, may mediate uptake into distinct intracellular trafficking routes, as suggested by Lencer and colleagues [92].

Modulation of RA currents by external Ca2+ is distinct in capsaicin-sensitive and insensitive neurons [9] and the mechanical thresholds of the two cell types are different, implying that distinct ion channels may mediate RA currents in nociceptors and non-nociceptors.