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Increased levels of proinflammatory cytokines such as IL-1, TNF-alpha, and IFN-gamma that are seen in psoriasis are purported to act as neuromodulators and may mediate depressive disorders.
Because depression and fatigue have a complex relationship in people with MS, and fatigue may mediate depressive features [ 39], after controlling for fatigue as a potential confounder in multivariate analyses, we additionally compared models both with and without fatigue.
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What is clear is that depressive symptoms and personality traits may mediate part of this discrepancy.
Depressive, anxiety symptoms and perceived social support may mediate this association.
These neuropathologic alterations may mediate or respond to the emotional, behavioral, and cognitive manifestations of depressive episodes.
Such findings are consistent with the hypothesis that negative events play a central role in the development of depressive symptoms and highlight the importance of discovering factors that may mediate [ 4] or moderate [ 26] this association - such as coping flexibility.
Some experts believe that they may mediate the effects of other cannabinoids.
Both moieties may mediate atherogenicity.
High-glucose environment may mediate these findings.
Higher BMI may mediate this association.
Instead, direct inhibition of pathological limbic activity in areas such as the amygdala and sgACC may be more essential to correcting the pathophysiology associated with mediating depressive symptoms, and the reduction in orbital cortex/VLPFC activity may reflect a secondary relaxation of these areas, once they are no longer recruited to modulate pathological limbic activity.
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