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Microglia have recently been shown to interact with neural stem cells and these cells may mediate both positive [38], [39] and negative effects on NPCs (this study).
Microparticles may mediate both systemic inflammation and DIC in sepsis.
Thus, P-DUDES proteins may mediate both apoptosis and autophagy which suggests for its broader function.
Hopelessness may mediate both depression and ideation but may influence each within different time frames.
Thus, cerebellar alpha oscillations may mediate both cerebrocerebellar as well as cortical communication, such as the frontoparietal network [ 35, 38].
On the other hand, the activation of TLRs may mediate both activation and inhibition of osteoclastic differentiation and related bone resorption.
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Although it is not known whether the deletion of Sp185/333 genes on 181662 was based on instability from the GA microsatellites, it is intriguing that these microsatellites may mediate gene both duplication and deletion.
These oestrogen-mimicking effects may be mediated both via the oestrogen receptor (ER) (Byrne et al, 2009) and through alternative pathways in the absence of ERs (Filardo et al, 2008; Yu et al, 2010).
Importantly, such feedback may be mediated both at the immediate interface between tumour cell and cytotoxic lymphocyte, and by the establishment of a wider immune suppressive milieu in the tumour microenvironment.
Cellular response to E2 may be mediated both by ER binding to the estrogen response element and by nonnuclear actions such as activation of signal-transducing pathways (ER independent) (Guo et al. 2006).
Thus LGI3 may mediate endocytosis for both syntaxin1 and amyloid peptides.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com