Sentence examples for may mediate bone from inspiring English sources

RANKL is also expressed by lymphocytes and synovial fibroblasts and may mediate bone loss associated with inflammatory conditions [ 35, 36].

These inflammatory cytokines may mediate bone loss directly by stimulating osteoclast formation and maturation or indirectly by promoting RANKL release, thereby increasing osteoclast activity 15, 51.

These monocyte-derived osteoclasts then mediate bone destruction.

Akt1 may mediate the osteoblastic bone formation by IGF-I and insulin, since their effects on osteoblast survival and differentiation were impaired in Akt1-/ osteoblasts (Fig 2C, 4A).

Our study further verifies that NOS may mediate load induced bone formation at the periosteal surface in loading and fatigue loading groups.

Furthermore, several studies have demonstrated that TRβ may mediate T3 actions in bone and cartilage (9 – 12), even though the principal physiological effects are mediated by TRα1.

Mature osteoclasts have been shown to express Flt-1 and Flk-1 on their cells surface [ 1, 8- 12] and both of these receptors may mediate the VEGF-A effect on bone formation and bone resorption [ 8].

This raises the possibility that changes in tibial bone size may mediate the effect of biomechanical factors on the pathogenesis of knee OA.

Our findings provide a foundation for future more detailed histomorphometric 42 or micro-CT studies that would explore other aspects of articular and subchondral bone structure that may mediate pain but could not be measured in this study.

In addition, a variety of bone-marrow-derived cells may mediate resistance to VEGF inhibition by producing proangiogenic factors [ 7, 8].

To test the hypothesis that Wnt7b may mediate some aspects of Ihh function during endochondral bone development, we activated Wnt7b expression from the R26-Wnt7b allele with Col2-Cre in the Ihh −/− mouse.