Dubey GP, Ben-Yehuda S: Intercellular nanotubes mediate bacterial communication.
These include adhesins and membrane proteins that mediate bacterial attachment, colonization, and invasion of host cells.
It is, therefore, possible that the PAAR repeat proteins encoded by genes located in the vgrG island of P. ananatis T6SS-1 gene cluster may either be T6SS effectors associated with inter-bacterial competition or may mediate secretion of other effectors.
Mtb-directed antibodies may mediate effector functions such as opsonization of bacterial cells, neutralization of secreted antigens, and antibody-dependent cellular cytotoxicity (ADCC) [ 16, 17] (summarized in Figure 1).
The KOW1 domain also contacts the bacterial termination factor ρ and may mediate ρ action on nearby exiting RNA.
All together these results suggest that XacFhaB, secreted or associated with bacterial membranes in a non-covalent manner, may mediate the attachment of X. axonopodis pv.
The function of the HTH domain is unknown but bacterial two-hybrid data indicated that it may mediate important interactions between RodZ and MreB.
The bacterial recA gene or the recombination systems of the MGEs themselves may mediate the generation of hybrid MGEs [ 25].
Genome rearrangements may occur via homologous recombination of repeat elements in the bacterial genomes [ 35, 36]. A. actinomycetemcomitans genomes contain diverse repeat elements that may mediate genome rearrangement.
Moreover, coevolving sites within a bacterial group mapped to regions previously identified as involved in folding-unrelated functions, and thus, coevolution may mediate alternative functions.
