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Even though the precise site where migraine origins still remains elusive, consistent evidence suggests that initial mechanisms may dilate intra- and extra-cerebral arteries, and cranial vasoconstriction may mediate at least a part of the effects of anti-migraine abortive drugs [8].
These findings are consistent with the hypothesis that epigenetic mechanisms may mediate at the molecular level the effects of life events on AD risk, and provide, for the first time, a potential explanation for AD discordance despite genetic similarities.
Thus, upregulation of BDNF may mediate at least part of the neuroprotective effect of SSRIs.
In simple terms, mTOR/S6K may mediate, at least in part, the pro-oxidant action of p66.
Nevertheless, animal studies have suggested that an increase in hippocampal neurogenesis may mediate, at least in part, the exercise-induced increase in cognitive function [ 54, 55].
Because resveratrol consumption appears to reduce atherosclerosis [ 26, 27], and activates SIRT1, SIRT1 may mediate at least part of this protective response [ 16].
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These hub SNPs may mediate interactions at an unknown gene regulatory level, e.g. as non-coding RNAs, miRNAs or cis-regulatory elements.
Along with hydrophobic contacts, several other interactions including the formation of coordination bonds, ionic interactions, van der Waals' contacts, electrostatic interactions, hydrogen bondings and (pi - pi) stackings may mediate Fpi - pimerization at the oligomeric interface.
Cardiomyocyte apoptosis is an important remodeling event contributing to heart failure and adiponectin may mediate cardioprotective effects at least in part via attenuating apoptosis.
In first binding to the ILM, the presence of high levels of heparan sulfate in the proteoglycan matrix of the ILM may mediate viral accumulation at this site and act as a 'sink' [40].
During polarization, EB1 and its binding partners may mediate microtubule capture at the cortical actin patch (or Arp2/actin network).
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