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Tribe's strength lies less in its statistical analysis, and more in its attempts to understand how culture may mediate an individual's experience of trauma – and what that tells us about society as a whole.
Oestrogen withdrawal may mediate an increased sensitivity to somatosensory stimuli in women with migraine attacks recurring during the hormone-free interval.
Fibrotic lesions and myofibroblasts have also been found in the tumor microenvironment prior to cancer cell invasion into the stroma suggesting that myofibroblasts may mediate an invasive phenotype [37].
So, if someone has had prior unsuccessful or negative therapeutic experiences or was provided information in a negative light, it may mediate an undesirable outcome to the therapy.
In addition to a BAG domain, BAG1 contains a ubiquitin-like domain which may mediate an interaction with the 26S proteasome [54].
Another interesting possibility to consider is the direct proteolysis of receptor-bound VEGF by cell-surface proteases; due to receptors' slower VEGF dissociation rates (koff = 10−3 s−1) compared to HSPGs (koff = 10−2 s−1), they may mediate an even more sensitive protease response curve than that seen with HSPGs (Fig. 4B).
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As such, autophagy is initially an adaptive response to ensure survival but beyond a certain threshold may mediate a form of non-caspase-mediated cell death.
In rice roots, Zn-induced activation of 40- and 42-kDa MAPK was suppressed by treatment with a ROS scavenger, suggesting that second messenger ROS may mediate a Zn-triggered MAPK pathway [98].
Overexpression of Parkin eliminates mitochondria with deleterious mutations in cytochrome oxidase subunit I (COXI) (Suen et al., 2010), suggesting that Parkin may mediate a mitochondrial quality control pathway to maintain organelle homeostasis.
However, IR-phosphorylated IRS6 does not bind to any SH2 domain-containing proteins, which indicates that it may mediate a different branch of the insulin signaling pathway (Cai et al., 2003).
IFNα may mediate a restriction that targets the viral gag-pol.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com