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Ceramics, and use of highly cross-linked polyethylene and of metal-on-metal articulations show promise as approaches that may markedly reduce the production of wear particles.
The experience of breathlessness may markedly reduce patients' functional ability [ 1, 3, 8], and fear of this symptom can itself lead to activity avoidance [ 10, 11].
A recent review of reviews also suggests that electronic brief interventions (eBIs) using internet and smartphone technologies may markedly reduce alcohol consumption compared with minimal or no intervention controls.
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Accumulating evidence indicates that clinical treatment of statins may not only markedly reduce plasma LDL-c levels but also significantly improve the clinical outcomes of the patients at high risk of atherosclerosis cardiovascular disease.
Previous reports have indeed shown that DDAH activity and protein expression may be markedly reduced during oxidative stress and/or inflammation [52 54].
With significant improvements in glycemic control, long-term complications of diabetes and their associated costs may be markedly reduced.
This suggests that the global effective 'CRT-dose' may be markedly reduced compared with atrial-synchronous rhythm with a short AV interval (as is achieved during SR) since the number of effective biventricular captured beats are reduced.
When comparing the present findings with those of young subjects, the vasodilatory potency of adenosine in particular may be markedly reduced by aging and further aggravated with diabetes, in correlation to the grade of endothelial affection.
By using a sample of observations that are each considered as an estimate of the same phenomenon, as opposed to treating observations individually, sampling error may be markedly reduced, while retaining true signal.
35 Interestingly, data suggest that the frequency of VTE may be markedly reduced when bortezomib is combined with IMiD-based regimens with high thrombogenic potential, even when no thromboprophylaxis was administered.
Their reproductive lifespan may however be markedly reduced, and AMH may be of value to detect that and predict remaining duration of potential fertility.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com