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The SNP-array analysis failed to detect recurrent small deletions, which may mark loci of genes involved in the tumor development.
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A hemizygous loss of 22 Mb was seen at chromosome 14q31.3-q32.33 in one of the ROs, which may mark the loci of candidate genes.
We have applied high-density SNP-oligoarray to detect copy number alterations at specific chromosomal regions in chromophobe RCCs and ROs, which may mark the loci of genes involved in tumor development.
Recent development in the array technology enables the detection of small DNA copy number changes throughout the entire genome, which may mark the locus of putative tumor genes.
Loci showing unusually large amounts of differentiation may mark regions of the genome that have been subject to directional selection, while loci showing unusually small amounts of differentiation may mark regions of the genome that have been subject to balancing selection [ 23].
The remaining putative loci were not near chromosomal regions previously associated with shoot ureide concentration and may mark new genes involved in ureide metabolism.
It may even mark his public rehabilitation.
Marker loci were used for management (see below) and non-marker loci were used for measuring diversity.
Marker loci with minor allele frequencies (MAFs) below 1% were excluded.
Marker loci parameters (map position, number of alleles, observed informative meioses etc).
Marker loci were ordered as in Ensembl map [ 16] (Table 1).
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