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Furthermore subsequent modelling studies were aimed to generate insights on more stringent targets, and on issues and uncertainties that may make targets harder to achieve.
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Astronomers may make "Target of Opportunity" proposals, in which observations are scheduled if a transient event covered by the proposal occurs during the scheduling cycle.
These genes may make effective targets for drug discovery efforts, as drugs targeting genes with bacterial origins are less likely to have an impact on their human host (Umejiego et al. 2008; Keeling 2009; Alsmark et al. 2013).
But for kinases, the inactive forms may make better targets, says Kuriyan.
The researcher may be particularly interested in the "hypothetical" or "unknown" query proteins that are ranked well according to RhuPDB (in the top ∼100) as these may make excellent targets for novel research into characterisation, validation, crystallography/modelling and virtual high throughput screening.
Highly conserved microsatellites in the promoters of developmental regulators like igf1 may make useful targets for quantitative genetics studies.
The large quantity of hypothetical proteins that are differentially expressed in response to anaerobiosis may make appealing targets for future study.
Given that the correction of genetic mutations is not a feasible cancer therapy, epigenetic alterations caused by environmental factors may make better targets.
Some FcRs found on adaptive immune cells may make better targets for Fc-fusions based on antibody classes other than IgG.
Moreover, bullying and CMD may also have reciprocal associations [ 30] due to stigmatization: mentally ill people may have problems coping with their daily tasks and cooperating with colleagues, which in turn may make them targets of bullying [ 57].
Issues such as shoddy work and technical errors may make that target unrealistic.
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